Physiologic Response to Surgery

The magnitude, invasiveness, and duration of surgery determine the degree of the body's integrated response.

Neuroendocrine–metabolic response

Inflammatory-Immune Response

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Promotes healing but it could also lead to harm

 

Where is the line fo demarcation?

 The body's attempt to maintain physiological homeostasis perioperatively induces a non-specific adaptation response that can be detrimental and lead to systemic inflammatory response syndrome (SIRS), hyper-metabolism, and hyper-catabolism.

Further injury may cause loss of normally functioning negative-feedback systems leading to muscle wasting, impaired immune function, impaired wound healing, and the potential for organ failure and death.

 

Surgery